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Mol Cell Endocrinol. 2012 Mar 24;350(2):151-62. doi: 10.1016/j.mce.2011.07.034. Epub 2011 Aug 4. Authors Namita G Hattangady 1 , Lawrence O Olala, Wendy B Bollag, William E Rainey. Affiliation 1 Department of Physiology, Georgia Health Sciences University (formerly Medical College of Georgia), 1120 15th Street, Augusta, GA 30912, USA..
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Since in EtOH self-administered mice the expression of OlAla significantly elevated in the principle areas of the reward system (PFC, NAc, and VTA, Fig. 2B and Table 1), we hypothesized that OlAla.
Electron Micrograph
OlGly and OlAla suppress EtOH self-administration and preference. We have previously shown that OlGly was elevated in a region-speci c manner in the NAc of male mice chronically treated with fi.
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Freely permeable layer surrounding cell membrane. The cell wall of plant cells is made from cellulose. This gives them a rigid structure. Supports and strengthens cell. Plant cell, fungal cell or.
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Coelution of OlAla with an isobaric compound (shown separated in Figure 2 with the presented mobile phase gradient) occurred when the starting mobile phase was 60% mobile phase B which did not allow an isobaric compound of OlAla to chromatographically resolve. Using the presented method allowed for the separation of potential interferences from isobaric compounds found in the brain tissue samples.
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Aldosterone is a major mineralocorticoid steroid hormone secreted by glomerulosa cells in the adrenal cortex. It regulates a variety of physiological responses including those to oxidative stress, inflammation, fluid disruption, and abnormal blood pressure through its actions on various tissues including the kidney, heart, and the central nervous system. Aldosterone synthesis is primarily.
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The endogenous amide N-Oleoylglycine (OlGly) and its analog N-Oleoylalanine (OlAla), have been shown to interfere with the affective and somatic responses to acute naloxone-precipitated MWD in male rats.Here we evaluated the potential of a single dose (5 mg/kg, ip) which alleviates withdrawal of these endogenous fatty acid amides to modify tolerance to anti-nociception, hyperthermia, and.
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Olala aims to optimize the annotation process by selectively annotating only the most ambiguous regions within an image, while using automatically generated labels for the rest. Central to Olala is a perturbation-based scoring function that determines which objects require manual annotation. Extensive experiments show that Olala can.
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Highlights Aldosterone is the major mineralocorticoid produced by the adrenal zona glomerulosa. Glomerulosa cells are primarily regulated by angiotensin II, serum potassium and ACTH. Aldosterone synthesis involves two key phases, acute and chronic. Cholesterol delivery into mitochondria is the rate-limiting step in the acute phase. Aldosterone synthase (CYP11B2) is the rate-limiting step in.
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Rationale The fatty acid amide oleoyl glycine (OlGly) and its more stable methylated form oleoyl alanine (OlAla) reduce naloxone-precipitated morphine withdrawal (MWD)-induced conditioned gaping (nausea) responses in rats. In addition, OlGly has been shown to reduce lithium chloride (LiCl)-induced conditioned gaping in rats and vomiting in Suncus murinus (house musk shrews). Objectives Here.
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Primary aldosteronism (PA) is one of the most frequent curable forms of secondary hypertension. It can be caused by the overproduction of aldosterone in one or both adrenal glands. The most common subtypes of PA are unilateral aldosterone over-production due to aldosterone-producing adenomas (APA) or bilateral aldosterone over-production due to bilateral hyperaldosteronism (BHA). Utilizing the.
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